Cell Tree Rings
Combining somatic genotype with cellular phenotype on the single cell level to assess biological age
Combining somatic genotype with cellular phenotype on the single cell level to assess biological age
mutations with evolutionary cell lineage trees Smarter and cheaper way to measure scalable single cell somatic mutation burden across the life sciences market space Cell Tree Rings is the first industry-developed, scalable and application focused tool that is ready to unleash the power of evolutionary cell lineage trees using somatic mutations from thousands of individual cells. It achieves this goal by a methodological disruption, calling somatic mutations from a modified version of the most available and affordable scRNAseq protocol by 10x Genomics. This is order of magnitude cheaper than the current, mostly academic single cell DNA sequencing of whole genomes to build the trees and it provides transcriptomics data directly from the same cells the mutations are coming from. The other key component is comprehensive cell tree analytics where we have used advanced math solutions from signal processing and physics to factor in every bifurcation on the tree. Current aging clocks used to assess healthy longevity interventions do not measure somatic mutation burden, which informs of the foundational aging hallmark genome instability. Not measuring existing somatic mutation burden before an intervention, the current default practice, can potentially offset biological age assessment by decades, and not assessing the potential changes in that burden due to and after the intervention can miss important additional mechanisms, effects and opportunities. We believe that Cell Tree Rings can serve as a core component for combined aging clocks to mitigate current uncertainty in the assessment of geroprotective trials.
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